How to use Collagen dressing for external wounds?
Collagen is the most abundant protein in the human body and is a major component of the extracellular matrix (ECM). It is comprised of three polypeptide chains that are rich in hydroxy-proline amino acids and are twisted together into a triple-helical structure. Over 20 different types of collagens have been identified in humans; the main types are type I, II, and III; and together they make up 80% of the body’s collagen. Type I and III are important for wound healing. In a healing wound, a cascade of events occurs and is broken into what is known as the phases of wound healing. These include platelet accumulation, inflammation, fibroblast proliferation, cell contraction, angiogenesis and re-epithelialization. This cascade ultimately leads to scar formation and wound remodeling . Collagen plays an important role in each of these phases of wound healing due to its chemotactic role. It attracts cells such as fibroblasts and keratinocytes to the wound. This encourages ...